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Fig. 2 | Molecular Cancer

Fig. 2

From: DNA damage response signatures are associated with frontline chemotherapy response and routes of tumor evolution in extensive stage small cell lung cancer

Fig. 2

SCLC DDR clusters are recapitulated in both in vitro and in vivo model systems. A DDR cluster heatmap for SCLC CellMiner cell line models. B SCLC cell line DDR cluster RepStress scores. C SCLC cell line DNA damage responsive transcription factor protein expression. D DNA repair protein expression across SCLC cell line DDR clusters. E Protein expression of DNA repair promoting effectors across DDR clusters. F G2/M cell cycle checkpoint effector protein expression in cell line DDR clusters. G DDR cluster heatmap for SCLC/hgNEC PDX and CDX models. H SCLC/hgNEC PDX/CDX DDR cluster RepStress scores. I SCLC/hgNEC PDX/CDX DDR cluster scRNAseq cell cycle state distribution

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Molecular Cancer

ISSN: 1476-4598