Table 1 scRNA-seq sample information
Timepoint | Sample ID | PFS (months) | Metastatic Site | CDK4/6i | ET agent |
|---|---|---|---|---|---|
Baseline (n = 8) | PA3 | 11 | Liver | Palbociclib | Fulvestrant |
PA5 | 38 | Pleural effusion | Palbociclib | Letrozole | |
PA45 | 23 | Liver | Palbociclib | Fulvestrant | |
PA95 | 12a | Liver | Palbociclib | Letrozole | |
PA110 | 31b | Pleural effusion | Palbociclib | Letrozole | |
PA120 | 33b | Liver | Palbociclib | Letrozole | |
PA131 | 28b | Liver | Abemaciclib | Letrozole | |
PA153 | 18 | Liver | Palbociclib | Letrozole | |
Early Progressor (n = 3) | PA46 | 5 | Pleural effusion | Palbociclib | Fulvestrant |
PA11 | 3 | Pleural effusion | Palbociclib | Fulvestrant | |
PA144 | 3 | Liver | Palbociclib | Fulvestrant | |
Late Progressor (n = 7) | PA1 | 13 | Pleural effusion | Palbociclib | Fulvestrant |
PA3 #1 | 11 | Ascites | Palbociclib | Fulvestrant | |
PA3 #2 | 11 | Ascites | Palbociclib | Fulvestrant | |
PA126 | 9 | Liver | Palbociclib | ZN-c5 | |
PA139 | 8 | Liver | Palbociclib | Letrozole | |
PA99 | 9 | Pleural effusion | Palbociclib | Anastrozole | |
PA165 | 37 | Pelvic bone | Palbociclib | Anastrozole |