Table 1 Marker genes for EC subtypes

Panendothelial

PECAM1, CDH5, CLDN5, ERG, PODXL, ST6GALNAC3, GALNT18, CAV1, CAV2, CAVIN1, CAVIN2, ITGA5, LAMB2, PRK2, SASH1, LDB2, PTK2, STARD13, FLI1, SOX18, ROBO4, TIE1, S1PR1

[4, 5, 15, 16]

Healthy lung ECs

capillary

CA4, HLA-II, PRX, RGCC, SGK1

[3,4,5]

general

VWF^pos/EMCN^low/EDN1, GPIHBP1, APLNR, IL7R, FCN3, BTNL8, CD14, IL18R, LPL, SLC6A

[3, 4, 15, 16]

aerocyte

VWF^neg/EMCN^high/EDNRB, APLN, HPGD, SOSTDC1, TBX2, SPON2, PRKG, CHRM2, S100A3, S100A4, EDA

[3, 4, 6, 15,16,17]

venous

ACKR1, VCAM1, VWF, CPE, CCL15, CCL23, SELP, NR2F2

[3,4,5, 15, 16]

systemic

COL15A1^pos

EBF1, EBF3, MEOX1, MEOX2, ZNF385D, TACR1, ROBO1, CYSLTR1, CPXM2, MMP16, PDE7B, PDE2A, SPRY1

[4]

pulmonary

COL15A1^neg

DKK3, PTGS1, PTGIS, C7, PLAT, PROCR, THBD, C1R, EFEMP1, CDH11

[4]

artery

GJA5, DKK2, BMX, EFNB2, SOX17, CXCL12, FBLN5, IL33, SEMA3G, HEY1, LTBP4

[3,4,5, 15, 16]

lymphatic

PROX1, CCL21, PDPN, LYVE1, TFF3, MMRN1, AKAP12, FABP4, SNCG, GYPC, PPFIBP1, EFEMP1, FLT4, SEMA3A, SEMA3D, TBX1, HOXD3, NR2F1, GPR182

[3,4,5, 7, 15, 16]

Tumor ECs

tip

CXCR4, ANGPT2, FSCN1, PGF, ADM, PDGFB, LAMA4, LAMC1, LAMB1. SPARC, LXN, VIM, MARCKS, MYH9, MYO1B, CD93, MCAM, ITGA5, TCF4, SOX4, SMAD1, COL4A1, COL4A2, COL18A1, IGF2, IGF1R

[3, 18, 19]